6-(三氟甲基)吡啶-2-甲酸合成路线 （共 9 条）
反应条件
n-butyllithium in diethyl ether; hexane T=-75°C; 0.25 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: 2-bromo-6-(trifluoromethyl)pyridine With n-butyllithium in diethyl ether; hexane T=-70 - -40°C; 0.25 h; 2: carbon dioxide in diethyl ether; hexane T=-70 - 20°C; 3: With hydrogenchloride in water pH=3;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 39 ;
US 20050054627 A1
反应条件
n-butyllithium; 2-(dimethylamino)-ethanol in diethyl ether; hexane T=-75°C; 2 h;
参考文献
Schlosser, Manfred; Marull, Marc
European Journal of Organic Chemistry, 2003 , # 8 p. 1569 - 1575
反应条件
potassium permanganate in water Heating;
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 82 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave 3: 21 percent / KMnO4 / H2O / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave 2: 21 percent / KMnO4 / H2O / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-75°C; Product distribution; Further Variations:ReagentsSolvents;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1569 - 1575
反应条件
1: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 2: 36 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
