(6-三氟甲基-吡啶-2-基)-甲醇合成路线 （共 9 条）
反应条件
lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 2-bromo-6-(trifluoromethyl)pyridine With n-butyllithium in toluene T=-78°C; 2: N,N-dimethyl-formamide in toluene T=-78°C; 3: With methanol; sodium tetrahydroborate in toluene T=-78 - 20°C;
参考文献
EP2218711 A1, ;
Page/Page column 116 ;
反应条件
in N,N-dimethyl-formamide T=80°C; 8 h; Sealed tubeInert atmosphere;
参考文献
Organic Letters, , vol. 16, # 6 p. 1744 - 1747
反应条件
1: 82 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave 3: 21 percent / KMnO4 / H2O / Heating 4: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 43 percent / Cu, HMPA / 112 - 130 °C / autoclave 2: 21 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
1: 21 percent / KMnO4 / H2O / Heating 2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide 1.5 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 1 h;
参考文献
Nippon Soda Co., Ltd.
Patent: EP2218711 A1, 2010 ;
Location in patent: Page/Page column 116; 117 ;
反应条件
1: With thionyl chloride in dichloromethane
T=20°C; 4 h;
2: in water
pH=5;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2006/34004 A2, 2006 ;
Location in patent: Page/Page column 71 ;
WO 2006/034004 A2
