4-(苄氧基甲基)环己酮合成路线 （共 12 条）
反应条件
hydrogenchloride in tetrahydrofuran 72 h; Ambient temperature;
参考文献
Hays, Sheryl J.; Novak, Perry M.; Ortwine, Daniel F.; Bigge, Christopher F.; Colbry, Norman L.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 654 - 670
反应条件
hydrogen; palladium on activated charcoal in methanol; isopropyl alcohol 2 h; Yield given;
参考文献
Smith, Amos B.; Nolen, Ernest G.; Shirai, Ryuichi; Blase, Frances R.; Ohta, Mitsuaki; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7837 - 7848
反应条件
1: 84 percent / LDA / tetrahydrofuran 2: DIBAL / hexane; CH2Cl2 / 2 h / Ambient temperature 3: H2 / 5percent Pd/C / propan-2-ol; methanol / 2 h View Scheme
参考文献
Smith, Amos B.; Nolen, Ernest G.; Shirai, Ryuichi; Blase, Frances R.; Ohta, Mitsuaki; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7837 - 7848
反应条件
1: 84 percent / LDA / tetrahydrofuran 2: DIBAL / hexane; CH2Cl2 / 2 h / Ambient temperature 3: H2 / 5percent Pd/C / propan-2-ol; methanol / 2 h View Scheme
参考文献
Smith, Amos B.; Nolen, Ernest G.; Shirai, Ryuichi; Blase, Frances R.; Ohta, Mitsuaki; et al.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7837 - 7848
反应条件
1: 85 percent / NaH / tetrahydrofuran / 96 h / Ambient temperature 2: 97 percent / 2percent aq. HCl / tetrahydrofuran / 72 h / Ambient temperature View Scheme
参考文献
Stella Pharma Corporation; Osaka Prefecture University Public Corporation; KIRIHATA,Mitsunori; HATTORI,Yoshihide; UEHARA,Kohki; TAKENAKA,Hiroshi
Patent: EP2602261 A1, 2013 ;
反应条件
1: 85 percent / NaH / tetrahydrofuran / 96 h / Ambient temperature 2: 97 percent / 2percent aq. HCl / tetrahydrofuran / 72 h / Ambient temperature View Scheme
参考文献
Chini, Marco; Crotti, Paolo; Flippin, Lee A.; Macchia, Franco; Pineschi, Mauro
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1405 - 1412
反应条件
1: NaH / tetrahydrofuran View Scheme
参考文献
Chini, Marco; Crotti, Paolo; Flippin, Lee A.; Macchia, Franco; Pineschi, Mauro
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1405 - 1412
反应条件
1.1: toluene-4-sulfonic acid / toluene / 18 h / |Reflux 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / |Reflux 3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C 3.2: 18 h / 20 °C 4.1: hydrogenchloride / water / 1 h / 20 °C View Scheme
参考文献
Stella Pharma Corporation; Osaka Prefecture University Public Corporation; KIRIHATA,Mitsunori; HATTORI,Yoshihide; UEHARA,Kohki; TAKENAKA,Hiroshi
Patent: EP2602261 A1, 2013 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / |Reflux 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C 2.2: 18 h / 20 °C 3.1: hydrogenchloride / water / 1 h / 20 °C View Scheme
参考文献
Stella Pharma Corporation; Osaka Prefecture University Public Corporation; KIRIHATA,Mitsunori; HATTORI,Yoshihide; UEHARA,Kohki; TAKENAKA,Hiroshi
Patent: EP2602261 A1, 2013 ;
参考文献
Chini, Marco; Crotti, Paolo; Flippin, Lee A.; Macchia, Franco; Pineschi, Mauro
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1405 - 1412
