4-羟基-6-甲氧基香豆素合成路线 （共 14 条）
反应条件
sodium hydride in mineral oil T=0 - 100°C;
参考文献
Nolan, Karen A.; Doncaster, Jeremy R.; Dunstan, Mark S.; Scott, Katherine A.; Frenkel, A. David; Siegel, David; Ross, David; Barnes, John; Levy, Colin; Leys, David; Whitehead, Roger C.; Stratford, Ian J.; Bryce, Richard A.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7142 - 7156
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2003/106452 A2, 2003 ;
Location in patent: Page 78 ;
WO 03/106452 A2
反应条件
potassium hydroxide in methanol Hydrolysis; 0.5 h; Heating;
参考文献
Sosnovskikh; Kutsenko; Ovsyannikov
Russian Chemical Bulletin, 2000 , vol. 49, # 3 p. 478 - 481
反应条件
1: 1) BuLi, 2) ZnCl2, 3) PdCl2(PPh3)2, DIBAL-H / 1) THF, -78 deg C, 2) THF, -78 deg C, 3) THF, 0 deg C to RT 2: 84 percent / NaH / tetrahydrofuran / Heating 3: 85 percent / TFA / toluene / 1 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 28 p. 4995 - 4998
反应条件
1: 84 percent / NaH / tetrahydrofuran / Heating 2: 85 percent / TFA / toluene / 1 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 28 p. 4995 - 4998
反应条件
1: 3 h / 100 °C / Neat (no solvent) 2: Eaton’s reagent / 4 h / 70 °C / Neat (no solvent) View Scheme
参考文献
Synthetic Communications, , vol. 40, # 5 p. 732 - 738
反应条件
1: 55 percent / PhN(Me)MgBr / diethyl ether / 3 h / 20 °C 2: 95 percent / conc. HCl / 24 h / 20 °C 3: 74 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Chemical Bulletin, , vol. 49, # 3 p. 478 - 481
反应条件
1: 95 percent / conc. HCl / 24 h / 20 °C 2: 74 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Russian Chemical Bulletin, , vol. 49, # 3 p. 478 - 481
反应条件
Eaton’s reagent T=70°C; 4 h; Neat (no solvent);
参考文献
Synthetic Communications, , vol. 40, # 5 p. 732 - 738
反应条件
1: AlCl3, aluminium chloride / 3.5 h / 150 °C 2: sodium hydride / toluene / 4.5 h / 100 °C / |Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 3 p. 799 - 807
