4-氯-2-丁炔-1-醇合成路线 （共 37 条）
反应条件
1: 3-(chloro)-prop-1-yne With n-butyllithium in diethyl ether; hexane T=-78°C; 0.25 h; 2: formaldehyd in diethyl ether; hexane T=-78 - -20°C;
参考文献
Trost, Barry M.; Rudd, Michael T.
Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4763 - 4776
反应条件
pyridine; thionyl chloride in diethyl ether T=10 - 20°C; 16 h;
参考文献
Whitfield, Frank B.; Freeman, Diana J.; Last, John H.; Bannister, Peter A.; Kennett, Bruce H.
Australian Journal of Chemistry, 1982 , vol. 35, # 2 p. 373 - 384
反应条件
thionyl chloride; triethylamine in dichloromethane T=10 - 20°C;
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 15 p. 2133 - 2147
反应条件
sodium carbonate in benzene T=65 - 70°C; 16 h; Inert atmosphere;
参考文献
Ionovation GmbH; Rosemeyer, Helmut; Malecki, Edith; Korneev, Sergei; Werz, Emma; Gall, Karsten
Patent: EP2712869 A1, 2014 ;
Location in patent: Paragraph 0162 ;
反应条件
potassium hydroxide 6 h; Heating;
参考文献
Majumdar; Chatterjee
Synthetic Communications, 1998 , vol. 28, # 20 p. 3849 - 3863
参考文献
Alcon Laboratories, Inc.
Patent: US5547663 A1, 1996 ;
参考文献
ALCON LABORATORIES, INC.
Patent: EP904313 B1, 2001 ;
参考文献
Zeneca Limited; Zeneca Pharma S.A.
Patent: US6414148 B1, 2002 ;
US 6414148 B1
反应条件
in diethyl ether T=5°C;
参考文献
Bulletin de la Societe Chimique de France, , p. 4146 - 4152
参考文献
Bulletin de la Societe Chimique de France, , p. 817
