1-(2-溴乙氧基)-4-硝基苯合成路线 （共 22 条）
反应条件
1: sodium azide / N,N-dimethyl-formamide / 60 °C
2: hydrogen; palladium 10 on activated carbon / ethanol
View Scheme
参考文献
McDonnell, Mark E.; Bian, Haiyan; Wrobel, Jay; Smith, Garry R.; Liang, Shuguang; Ma, Haiching; Reitz, Allen B.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1116 - 1121
反应条件
1: sodium hydride / N,N-dimethyl-formamide
2: hydrogen; palladium 10 on activated carbon / ethanol
View Scheme
参考文献
McDonnell, Mark E.; Bian, Haiyan; Wrobel, Jay; Smith, Garry R.; Liang, Shuguang; Ma, Haiching; Reitz, Allen B.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1116 - 1121
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
McDonnell, Mark E.; Bian, Haiyan; Wrobel, Jay; Smith, Garry R.; Liang, Shuguang; Ma, Haiching; Reitz, Allen B.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1116 - 1121
反应条件
1: KOH / methanol / 20 °C
2: 70 percent / Fe; aq. HCl / 3 h / Heating
View Scheme
参考文献
Rajakumar, Perumal; Mohammed Abdul Rasheed; Iman Rabia; Chamundeeswari
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6019 - 6023
反应条件
potassium hydroxide in methanol
T=20°C;
参考文献
Rajakumar, Perumal; Mohammed Abdul Rasheed; Iman Rabia; Chamundeeswari
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6019 - 6023
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
T=20 - 60°C; 18 h;
参考文献
Butler, Christopher R.; Edwards, James P.; Fourie, Anne M.; Grice, Cheryl A.; Karlsson, Lars; Savall, Brad M.; Tays, Kevin L.; Wei, Jianmei
Patent: US2006/223792 A1, 2006 ;
Location in patent: Page/Page column 27 ;
US 20060223792 A1
参考文献
Prescher, Dietrich; Engler, Guenter; Blume, Annegret; Platanov, Viatcheslav E.; Osina, Olga I.
Zeitschrift fuer Chemie (Stuttgart, Germany), 1989 , vol. 29, # 9 p. 340 - 341
参考文献
Julia
Bulletin de la Societe Chimique de France, 1956 , p. 185,186
反应条件
in water; acetonitrile
T=80°C; 7 h;
参考文献
BIOMARIN PHARMACEUTICAL INC.; CHU, Daniel; WANG, Bing
Patent: WO2011/140009 A1, 2011 ;
Location in patent: Page/Page column 98 ;
反应条件
1: potassium carbonate / acetonitrile / 80 °C
2: palladium 10 on activated carbon; hydrogen / methanol
View Scheme
参考文献
Song, Hyeseung; Lee, Yun Suk; Roh, Eun Joo; Seo, Jae Hong; Oh, Kwang-Seok; Lee, Byung Ho; Han, Hogyu; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5668 - 5674
