(R)-1-Boc-3-氰基吡咯烷合成路线 （共 9 条）
反应条件
in N,N-dimethyl-formamide T=100°C; 18 h; Inert atmosphere;
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
Location in patent: Page/Page column 51 ;
反应条件
in dimethyl sulfoxide T=80°C; 4 h;
参考文献
ASTRAZENECA AB; ASTRAZENEKA UK LIMITED
Patent: WO2005/26156 A1, 2005 ;
Location in patent: Page/Page column 117 ;
WO 2005/026156 A1
反应条件
1: 93 percent / Et3N / CH2Cl2 2: 84 percent / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 21 p. 2417 - 2419
反应条件
in dimethyl sulfoxide; ethyl acetate; pentane
反应条件
in N,N-dimethyl-formamide Substitution;
参考文献
Kim, Yong Jip; Kaiser, Donald A.; Pollard, Thomas D.; Ichikawa, Yoshitaka
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2417 - 2419
反应条件
1: Et3N / methanol 2: 93 percent / Et3N / CH2Cl2 3: 84 percent / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 21 p. 2417 - 2419
反应条件
hydrogen in ethanol; water P=3102.97 Torr;
参考文献
GLAXOSMITHKLINE LLC; DOCK, Steven, Thomas; MCSHERRY, Allison, K.; MOORE, Michael, Lee; RIDGERS, Lance, Howard; PARRISH, Cynthia, Ann
Patent: WO2013/28445 A1, 2013 ;
Location in patent: Page/Page column 51; 52 ;
反应条件
hydrogenchloride in 1,4-dioxane; ethanol 2 h;
参考文献
GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia
Patent: WO2011/56635 A1, 2011 ;
Location in patent: Page/Page column 50-51 ;
WO 2011/056635 A1
