2-乙基-3,6-二甲基吡嗪合成路线 （共 67 条）
反应条件
potassium permanganate
参考文献
Stoehr
Journal fuer Praktische Chemie (Leipzig), 1893 , vol. <2> 47, p. 494,506, 508
Journal fuer Praktische Chemie (Leipzig), 1897 , vol. 55, p. 51
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Stoehr
Journal fuer Praktische Chemie (Leipzig), 1897 , vol. <2>55, p. 254
反应条件
potassium permanganate
参考文献
Stoehr
Journal fuer Praktische Chemie (Leipzig), 1893 , vol. <2> 47, p. 494,506, 508
Journal fuer Praktische Chemie (Leipzig), 1897 , vol. 55, p. 51
反应条件
1: ethyl bromide With magnesium in tetrahydrofuran
2: 3-chloro-2,5-dimethyl-pyrazine With 1-methyl-pyrrolidin-2-one; iron (III) acetylacetonate
T=0°C; 0.25 h;
参考文献
Dickschat, Jeroen S.; Wickel, Susanne; Bolten, Christoph J.; Nawrath, Thorben; Schulz, Stefan; Wittmann, Christoph
European Journal of Organic Chemistry, 2010 , # 14 p. 2687 - 2695
反应条件
iron sulphate heptahydrate; sulfuric acid; dihydrogen peroxide in water
T=0°C; Minisci Aromatic Substitution; Green chemistry;
参考文献
Bohman, Bjorn; Berntsson, Benjamin; Dixon, Ruby C. M.; Stewart, Craig D.; Barrow, Russell A.
Organic Letters, 2014 , vol. 16, # 11 p. 2787 - 2789
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran; hexane
3 h; Ambient temperature;
参考文献
Sato, Nobuhiro; Matsuura, Tomoyuki
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 19 p. 2345 - 2350
反应条件
1: 61 percent / phosphoryl chloride / Heating
2: 71 percent / <1,3-bis(diphenylphosphino)propane>nickel(II) chloride / tetrahydrofuran; hexane / 3 h / Ambient temperature
View Scheme
参考文献
Sato, Nobuhiro; Matsuura, Tomoyuki
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 19 p. 2345 - 2350
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
Heating;
参考文献
Ohta, Akihiro; Ohta, Masakatsu; Igarashi, Yoshiaki; Saeki, Kaemi; Yuasa, Kayo; Mori, Tomoko
Heterocycles, 1987 , vol. 26, # 9 p. 2449 - 2454
参考文献
Klein; Spoerri
Journal of the American Chemical Society, 1951 , vol. 73, p. 2949
反应条件
tetrakis(triphenylphosphine) palladium(0); diethylzinc; potassium carbonate in N,N-dimethyl-formamide
Heating;
参考文献
Ohta, Akihiro; Ohta, Masakatsu; Igarashi, Yoshiaki; Saeki, Kaemi; Yuasa, Kayo; Mori, Tomoko
Heterocycles, 1987 , vol. 26, # 9 p. 2449 - 2454
反应条件
1: Et3N / CH2Cl2 / 10 - 20 °C
2: toluene / 300 °C
View Scheme
参考文献
Buechi, George; Galindo, Jose
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2605 - 2606
