1: thionyl chloride; chlorosulfonic acid / 20 °C 2: sodium hydroxide / water / 2.08 h / 10 - 20 °C 3: ethyl acetate / 2.5 h / 55 °C / |Reflux 4: ethyl acetate / 70 h / 20 °C View Scheme
参考文献
Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S.
Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22
1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation 2: ammonia / 1,4-dioxane; water / 72 h / 20 °C 3: sodium ethanolate / ethanol / 0.17 h / 120 °C / Microwave irradiation View Scheme
参考文献
Wang, Cuihua; Ashton, Trent D.; Gustafson, Alden; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2579 - 2581
1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation 2: ammonia / 1,4-dioxane; water / 72 h / 20 °C View Scheme
参考文献
Wang, Cuihua; Ashton, Trent D.; Gustafson, Alden; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2579 - 2581
1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation 2: ammonia / 1,4-dioxane; water / 72 h / 20 °C 3: sodium ethanolate / ethanol / 0.17 h / 120 °C / Microwave irradiation View Scheme
参考文献
Wang, Cuihua; Ashton, Trent D.; Gustafson, Alden; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2579 - 2581
