1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 1.2: 40 h / -40 °C / Inert atmosphere 2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere View Scheme

1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 1.2: 40 h / -40 °C / Inert atmosphere 2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 5.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1.1: AlCl₃, aluminium chloride / 1.5 h / 100 &deg;C / Inert atmosphere<br />2.1: BH₃*N,N-diethylanilline; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene / 6 h / 25 &deg;C / Inert atmosphere<br />3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 &deg;C / Inert atmosphere<br />3.2: 0 - 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: AlCl₃, aluminium chloride / 1.5 h / 100 &deg;C / Inert atmosphere<br />2.1: BH₃*N,N-diethylanilline; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole / toluene / 6 h / 25 &deg;C / Inert atmosphere<br />3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 &deg;C / Inert atmosphere<br />3.2: 0 - 20 &deg;C / Inert atmosphere<br /> <br /> &nbsp;