反应条件
1: p-toluenesulfonic acid / 0.67 h / Ambient temperature 2: 1.) Mg / 1.) THF, reflux, 2.) reflux, 4 h 3: p-toluenesulfonic acid / benzene / 0.5 h / Heating 4: p-toluenesulfonic acid / methanol / 24 h / Ambient temperature 5: Zn / diethyl ether / 0.5 h / Heating 6: Zn, NH4Cl / methanol / 3 h / Heating 7: molecular sieves 3A, pyridine / 72 h / Ambient temperature 8: 1.) p-toluenesulfonyl chloride, 2.) H2O / 1.) pyridine, 0 deg C, 15 h, 2.) overnight 9: 94 percent / K2CO3 / methanol / 3 h / Ambient temperature 10: 90 percent / BH3*THF / tetrahydrofuran / 2 h / Heating 11: 91 percent / Jones reagent / acetone / 0.33 h / 0 °C 12: 71 percent / base / acetone View Scheme
参考文献
Jeffs, Peter W.; Cortese, Nicholas A.; Wolfram, Joachim
Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3881 - 3886
