(2,4-二氟苯基)-4-哌啶基甲酮肟盐酸盐合成路线 (共 6 条)
反应条件
thionyl chloride; hydroxylamine hydrochloride; acetic anhydride; aluminium trichloride in hydrogenchloride; ethanol
反应条件
1: ammonium chloride / dichloromethane / 3 h / 20 °C / Reflux 2: hydrogenchloride / water / 5 h / Reflux 3: hydroxylamine hydrochloride; 2-(dimethylamino)-ethanol / ethanol / 3 h / 20 °C / Reflux View Scheme
反应条件
1: ammonium chloride / dichloromethane / 3 h / 20 °C / Reflux 2: hydrogenchloride / water / 5 h / Reflux 3: hydroxylamine hydrochloride; 2-(dimethylamino)-ethanol / ethanol / 3 h / 20 °C / Reflux View Scheme
反应条件
1: hydrogenchloride / water / 5 h / Reflux 2: hydroxylamine hydrochloride; 2-(dimethylamino)-ethanol / ethanol / 3 h / 20 °C / Reflux View Scheme
反应条件
water; sodium hydroxide 4 h; Reflux;
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
sodium carbonate; potassium iodide in acetonitrile 32 h; Heating / reflux;
参考文献
AUROBINDO PHARMA LTD.; MEENAKSHISUNDERAM, Sivakumaran; RAMA, Shankar; CHETAN, Pandit
Patent: WO2004/9591 A1, 2004 ;
Location in patent: Page 7 ;