potassium tert-butylate in dimethyl sulfoxide T=25°C; 3.2 h; Inert atmosphere; regioselective reaction;

1: n-butyl-magnesium chloride With 1,3-dimethyl-2-phenyl-1H-imidazol-3-ium iodide in tetrahydrofuran T=0°C; 2: 3-chloro-1-cyclohexylprop-1-ene in tetrahydrofuran T=0 - 20°C;

copper(I) bromide dimethylsulfide complex; O,O’-(S)-1,1’-(dinaphthyl-2,2’-diyl)-N,N’-di-(S,S)-1-(2-methoxyphenyl)ethylphosphoramidite in hexane; dichloromethane T=-80°C; 5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

Yield given. Multistep reaction;