1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4.5 h;
2: 1-bromo-2-ethyl butane With n-butyllithium in tetrahydrofuran; hexane
T=10 - 20°C; 21.5 h;
3: With hydrogenchloride in water
pH=1 - 2; Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 5; 6 ;
1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diethylamine in tetrahydrofuran; hexane
T=20°C; 4.5 h;
2: toluene-4-sulfonic acid 2-ethyl-butyl ester in tetrahydrofuran; hexane
T=10 - 20°C; 19.5 h;
3: With hydrogenchloride in water
Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 10 ;
1: cyclohexanecarboxylic acid Na-salt With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
2: neopentyl iodide With n-butyllithium in tetrahydrofuran; hexane
3: With hydrogenchloride in water
Product distribution / selectivity;
参考文献
F. Hoffmann-La Roche AG
Patent: EP1935867 A1, 2008 ;
Location in patent: Page/Page column 5 ;
