136918-14-4合成路线 （共 708 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Forschungszentrum Borstel; Fujimoto, Naho; Röckendorf, Niels; Bade, Steffen; Ramaker, Katrin; Frey, Andreas
Patent: US8501199 B2, 2013 ;
Location in patent: Page/Page column 18; 19; 23 ;
反应条件
1: 88 percent / CH2Cl2 / 3 h / 0 °C
2: 90 percent / triethylsilane; trifluoroboron etherate / CH2Cl2 / -15 - 20 °C
View Scheme
参考文献
Kreher, Richard P.; Hennige, Hans; Konrad, Michael; Uhrig, Juergen; Clemens, Andrea
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 6 p. 809 - 828
反应条件
1.1: magnesium; iodine; triethylamine / diethyl ether / 1 h / |Reflux; |Inert atmosphere
1.2: 3 h / 20 °C / |Inert atmosphere
2.1: hydrogen; 1 wt Pd/C / methanol / 2 h / 22 °C / 15201 Torr / |Autoclave
View Scheme
参考文献
Sagirova; Starodubtseva; Turova; Vinogradov
Russian Chemical Bulletin, 2013 , vol. 62, # 4 p. 1032 - 1037
Izv. Akad. Nauk, Ser. Khim., 2013 , vol. 62, # 4 p. 6
反应条件
copper(I) oxide
T=100°C; 48 h;
参考文献
Kim, Guncheol; Keum, Gyochang
Heterocycles, 1997 , vol. 45, # 10 p. 1979 - 1988
反应条件
copper(I) oxide
T=100°C;
参考文献
Kim, Guncheol; Keum, Gyochang
Heterocycles, 1997 , vol. 45, # 10 p. 1979 - 1988
反应条件
1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / acetone / 24 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5885 - 5893
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0 - 20°C; 20 h;
参考文献
JAMES BLACK FOUNDATION LIMITED
Patent: EP1056733 B1, 2004 ;
Location in patent: Page 33 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0 - 20°C;
参考文献
Geyer, Roland; Igel, Patrick; Kaske, Melanie; Elz, Sigurd; Buschauer, Armin
MedChemComm, 2014 , vol. 5, # 1 p. 72 - 81
反应条件
triphenylphosphine in tetrahydrofuran; hexane
参考文献
SmithKline Beecham Corporation
Patent: US6403578 B1, 2002 ;
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Gabriel synthesis; 12.5 h; Inert atmosphere;
2: With hydrazine hydrate in ethanol
Gabriel synthesis; Inert atmosphereReflux;
3: With hydrogenchloride in water
Inert atmosphere;
参考文献
Tuchscherer, Andre; Schaarschmidt, Dieter; Schulze, Steffen; Hietschold, Michael; Lang, Heinrich
European Journal of Inorganic Chemistry, 2011 , # 28 p. 4421 - 4428
