136918-14-4合成路线 （共 708 条）
反应条件
triphenylphosphine in tetrahydrofuran
参考文献
G. D. Searle and Co.
Patent: US4933369 A1, 1990 ;
反应条件
1: potassium carbonate / acetonitrile / 13 h / 90 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
GREEN CROSS CORPORATION
Patent: US2012/232090 A1, 2012 ;
反应条件
potassium carbonate in acetonitrile
48 h; Inert atmosphereReflux;
参考文献
Zhou, Liang
Journal of Chemical Research, 2012 , vol. 36, # 9 p. 512 - 515
反应条件
PS-PPh3; di-isopropyl azodicarboxylate in tetrahydrofuran
T=20°C; Cooling with ice/water;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2009/91939 A1, 2009 ;
Location in patent: Page/Page column 59-60 ;
反应条件
polystyrene triphenylphosphine; di-isopropyl azodicarboxylate in tetrahydrofuran
T=0 - 20°C; 72 h;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2007/64993 A2, 2007 ;
Location in patent: Page/Page column 71 ;
WO 2007/064993 A2
反应条件
di-isopropyl azodicarboxylate in tetrahydrofuran
12 h;
参考文献
UNIVERSITY OF WASHINGTON; VAN VOORHIS, Wesley, C.; HOL, Wilhelmus, G.J.; LARSON, Eric, T.; MALY, Dustin, James; MERRITT, Ethan; OJO, Kayode, K.
Patent: WO2011/94628 A1, 2011 ;
Location in patent: Page/Page column 105 ;
WO 2011/094628 A1
反应条件
potassium carbonate in acetonitrile
48 h; Inert atmosphereReflux;
参考文献
Zhou, Liang
Journal of Chemical Research, 2012 , vol. 36, # 9 p. 512 - 515
反应条件
1: 71 percent / NEt3 / CH2Cl2 / 6 h / Heating
2: 75 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Chun; Park; Oh; Hong; Kim
Synthesis, 1994 , # 9 p. 909 - 910
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; toluene
T=20°C; 4.08333 h;
参考文献
KYORIN PHARMACEUTICAL CO., LTD.
Patent: EP1780210 A1, 2007 ;
Location in patent: Page/Page column 56 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
Ambient temperature;
参考文献
Vig, O. P.; Trehan, I. R.; Kad, G. L.; Ghose, J.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 5 p. 515 - 516
