136918-14-4合成路线 （共 708 条）
反应条件
sodium carbonate in CH2Cl2/MeOH; dichloromethane; trifluoroacetic acid
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
反应条件
ammonia; thorium(IV) dioxide T=410 - 485°C;
参考文献
Du Pont de Nemours and Co.
Patent: US2232836 , 1939 ;
Full Text Show Details
Imp. Chem. Ind.
Patent: DE624621 , 1934 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 22, p. 319
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATSUMOTO, Shigemitsu; ONO, Koji; TOMINARI, Yusuke; KATOH, Taisuke; MIWA, Kazuhiro; HASUOKA, Atsushi; IMAMURA, Shinichi
Patent: WO2013/18929 A1, 2013 ;
Location in patent: Paragraph 0456 ;
WO 2013/018929 A1
反应条件
sodium hydroxide; Methyl methyltrioctylammonium sulfate in toluene T=95°C; 4 h; different bases, other temperatures; Product distribution;
参考文献
Vasilevskaya; Grineva; Chernousova; Grankina; Andrievskii
Journal of applied chemistry of the USSR, 1987 , vol. 60, # 1 pt 2 p. 220 - 222
反应条件
sodium hydroxide in water; acetonitrile T=35°C; Kinetics; Further Variations:Solvents;
参考文献
Khan, M. Niyaz
International Journal of Chemical Kinetics, 2001 , vol. 33, # 1 p. 29 - 40
反应条件
hydrogenchloride; chlorine in hexane; toluene
反应条件
1: cyclohexyl-mercaptan With chlorine in benzene T=0°C; 1 h; 2: phthalimide With N-ethyl-N,N-diisopropylamine in benzene T=0 - 20°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 11 p. 3775 - 3784
反应条件
1: sodium hydride / N,N-dimethyl-formamide 2: lithium hydroxide hydrate; methanol / tetrahydrofuran View Scheme
参考文献
REPLIGEN CORPORATION
Patent: US2012/94971 A1, 2012 ;
反应条件
1.1: nitric acid; sulfuric acid / 16 h / 5 - 20 °C 2.1: potassium hydroxide / methanol; ethanol / 3 h / 20 °C 2.2: 1 h / |Reflux View Scheme
参考文献
Bian, Xiaoli; Wang, Qian; Ke, Changhu; Zhao, Guilan; Li, Yiping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2022 - 2026
