136918-14-4合成路线 （共 708 条）
反应条件
pyridine; oxygen; copper diacetate in dichloromethane
168 h;
参考文献
Huegel, Helmut M.; Rix, Colin J.; Fleck, Karin
Synlett, 2006 , # 14 p. 2290 - 2292
反应条件
pyridine; copper diacetate in dichloromethane
T=20°C;
参考文献
Huegel, Helmut M.; Rix, Colin J.; Fleck, Karin
Synlett, 2006 , # 14 p. 2290 - 2292
反应条件
[bis(acetoxy)iodo]benzene in 1,2-dichloro-ethane
T=140°C; 4 h;
参考文献
Kim, Hyun Jin; Kim, Jiyu; Cho, Seung Hwan; Chang, Sukbok
Journal of the American Chemical Society, 2011 , vol. 133, # 41 p. 16382 - 16385
反应条件
potassium hydroxide; 1-n-butyl-3-methylimidazolium tetrafluoroborate
T=60°C; 5 h;
参考文献
Le, Zhang-Gao; Chen, Zhen-Chu; Hu, Yi; Zheng, Qin-Guo
Synthesis, 2004 , # 2 p. 208 - 212
参考文献
Atkinson
Journal of the Chemical Society, 1954 , p. 1329
反应条件
chlorine; triethylamine in tetrahydrofuran; water; toluene
参考文献
The Goodyear Tire and Rubber Company
Patent: US3944552 A1, 1976 ;
反应条件
1: potassium carbonate / 190 °C
2: sodium ethylate; ethanol
View Scheme
参考文献
Schmid; Karrer
Helvetica Chimica Acta, 1948 , vol. 31, p. 1497,1500
反应条件
1: NH2NH2•xH2O / ethanol / 70 °C / |Cooling with ice
2: trichlorophosphate / ethanol / 4 h / |Reflux
3: NH2NH2•xH2O / ethanol / 60 °C
4: sodium nitrite; water; hydrogenchloride / 5 °C
View Scheme
参考文献
Wu, Yan; Sun, Liang-Peng; Ma, Long-Xu; Che, Jian; Song, Ming-Xia; Cui, Xun; Piao, Hu-Ri
Chemical Biology and Drug Design, 2013 , vol. 81, # 5 p. 591 - 599
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C;
参考文献
NEUROPHARMA, S.A.; RUFFLES, Graham, Keith
Patent: WO2004/32929 A2, 2004 ;
Location in patent: Page/Page column 23-25 ;
WO 2004/032929 A2
反应条件
1: 4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0°C; 0.333333 h;
2: phthalimide in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
TEIJIN LIMITED
Patent: EP1505067 A1, 2005 ;
Location in patent: Page/Page column 369 ;
EP 1505067 A1
