1.1: pyridine; phosphorus pentachloride / dichloromethane / 8 h / 0 °C 2.1: dichloromethane / 1 h / -30 - -20 °C 3.1: water / dichloromethane / 12 h / 20 °C 4.1: diisobutylaluminium hydride / dichloromethane; toluene / 12 h / -78 °C 5.1: n-butyllithium / diethyl ether / 0.5 h / 0 °C / Inert atmosphere 5.2: 2 h / 20 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C 7.1: pyridine; 4-(N,N-dimethlyamino)pyridine; acetic anhydride / dichloromethane / 0.33 h / 0 - 20 °C 7.2: 0.25 h / 20 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: sodium hydroxide / methanol; water / 2 h / 20 &deg;C<br />2: 4-(N,N-dimethlyamino)pyridine; BOP; triethylamine / N,N-dimethyl-formamide / 3 h / 20 &deg;C<br />3: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 24 h / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">4-(N,N-dimethlyamino)pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0 - 20&deg;C;&nbsp;24&nbsp;h;&nbsp;<br /> &nbsp;