hydrogenchloride; potassium permanganate in water

1: ethyl bromide With magnesium in tetrahydrofuran T=50°C; 2: 2,4-dichloro-5-fluoro-pyrimidine in tetrahydrofuran; ethylene glycol dimethyl ether T=0 - 15°C; 1 h; 3: With iodine; triethylamine in tetrahydrofuran; ethylene glycol dimethyl ether T=5 - 15°C;

hydrogenchloride; sodium hydroxide; ammonia in dichloromethane; water

1.1: sodium hydroxide / water / 0.5 h / 80 - 90 °C 1.2: pH 1 2.1: 5 palladium on charcoal; hydrogen / ethanol / 50 °C / 2585.81 Torr 3.1: triethylamine; trichlorophosphate / dichloromethane / 8 h / 40 °C / |Reflux 4.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / dichloromethane / 12 h / |Inert atmosphere; |Reflux View Scheme

1.1: sodium hydroxide / water / 0.5 h / 80 - 90 °C 1.2: pH 1 2.1: 5 palladium on charcoal; hydrogen / ethanol / 50 °C / 2585.81 Torr View Scheme

1: 5 palladium on charcoal; hydrogen; sodium acetate / methanol / 5 h / 50 °C / 2585.81 Torr 2: sodium hexamethyldisilazane / tetrahydrofuran; toluene / -60 °C 3: methanol; acetone / |Reflux 4: sodium hydroxide / water; dichloromethane / pH 11 View Scheme

1.1: sodium hydroxide / water / 0.5 h / 80 - 90 °C 1.2: pH 1 2.1: 5 palladium on charcoal; hydrogen / ethanol / 50 °C / 2585.81 Torr 3.1: triethylamine; trichlorophosphate / dichloromethane / 8 h / 40 °C / |Reflux View Scheme