1: thien-3-yl bromide With n-butyllithium in diethyl ether T=-78°C; Metallation; 0.5 h; 2: With tributyltin chloride in diethyl ether T=-70 - 20°C; Condensation; 2 h; 3: 4-bromo-thiophene-2-carbaldehyde With tetrakis(triphenylphosphine) palladium(0) in xylene T=140°C; Substitution; 2 h;