N-Boc-L-缬氨酸合成路线 （共 134 条）
反应条件
chloro-trimethyl-silane; phenol in dichloromethane Ambient temperature;
参考文献
Kaiser, Emil; Tam, James P.; Kubiak, Teresa M.; Merrifield, R. B.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 303 - 306
反应条件
in dichloromethane Ambient temperatureDeprotection of various Boc-amino acids was investigated. Effect of concentration of the deprotection reagent on the deprotection rates (t1/2) is determined.; Kinetics;
参考文献
Kaiser, Emil; Tam, James P.; Kubiak, Teresa M.; Merrifield, R. B.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 303 - 306
反应条件
(i) ClCO2iBu, Et3N, THF, (ii) /BRN= 1281877/; Multistep reaction;
参考文献
Wan, Qian; Chen, Jin; Yuan, Yu; Danishefskr, Samuel J.
Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15814 - 15816
反应条件
1: 67 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenztriazole 2: 1.) 4N HCl; 2.) N-methylmorpholine / 2.) 0.1M AcOH / 1.) dioxane, r.t., 30 min; 2.) 2-butanol, reflux, 3 h View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
反应条件
in methanol T=20°C; Sonication;
参考文献
Sahoo, Pathik; Sankolli, Ravish; Lee, Hee-Young; Raghavan, Srinivasa R.; Dastidar, Parthasarathi
Chemistry - A European Journal, 2012 , vol. 18, # 26 p. 8057 - 8063
反应条件
1: in tetrahydrofuran; water 0.166667 h; 2: With sodium tetrahydroborate in water 12 h;
参考文献
WO2014/5129 A1, ;
Page/Page column 150 ;
反应条件
1: ClCO2Et 2: AgO2CCF3 View Scheme
参考文献
Cheng, Jianjun; Ziller, Joseph W.; Deming, Timothy J.
Organic Letters, 2000 , vol. 2, # 13 p. 1943 - 1946
反应条件
1.1: 85 percent / Et3N / dimethylformamide / 0 - 20 °C 2.1: TFA / 1 h / 20 °C 2.2: 85 percent / HCl / dioxane; H2O View Scheme
参考文献
Yang, Peng-Yu; Wang, Min; Li, Lin; Wu, Hao; He, Cynthia Y.; Yao, Shao Q.
Chemistry - A European Journal, 2012 , vol. 18, # 21 p. 6528 - 6541
反应条件
phosphorus trichoride in dichloromethane T=0°C; 2 h;
参考文献
Akssira; Boumzebra; Kasmi; Dahdouh; Roumestant; Viallefont
Tetrahedron, 1994 , vol. 50, # 30 p. 9051 - 9060
反应条件
N-ethyl-N,N-diisopropylamine; PyCloP in dichloromethane 3 h; Ambient temperature;
参考文献
Frerot, Eric; Coste, Jacques; Poncet, Joel; Jouin, Patrick; Castro, Bertrand
Tetrahedron Letters, 1992 , vol. 33, # 20 p. 2815 - 2816
