D-(-)-酒石酸二乙酯合成路线 （共 19 条）
反应条件
1: 30percent HBr / 1) 0 deg C, 15 min, 2) rt, 4 h 2: 1) 30percent HBr, AcOH, 2) EtONa / 1) EtOH, reflux, 2) EtOH, rt View Scheme
参考文献
Schiefer, Isaac T.; Tapadar, Subhasish; Litosh, Vladislav; Siklos, Marton; Scism, Rob; Wijewickrama, Gihani T.; Chandrasena, Esala P.; Sinha, Vaishali; Tavassoli, Ehsan; Brunsteiner, Michael; Fa', Mauro; Arancio, Ottavio; Petukhov, Pavel; Thatcher, Gregory R. J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6054 - 6068
反应条件
N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate in 2,2,4-trimethylpentane; water; ethyl acetate; acetone; acetonitrile
参考文献
Astra Aktiebolag
Patent: US5929244 A1, 1999 ;
US 5929244 A
反应条件
N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate in toluene
参考文献
Astra Aktiebolag
Patent: US5948789 A1, 1999 ;
US 5948789 A
反应条件
N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate in dichloromethane; water; acetonitrile
参考文献
Astra Aktiebolag
Patent: US5948789 A1, 1999 ;
US 5948789 A
反应条件
tetrabutylammonium dioxovanadium(V)-dipicolinate; triphenylphosphine in benzene T=170°C; 96 h; Sealed tube; stereoselective reaction;
参考文献
Chapman Jr., Garry; Nicholas, Kenneth M.
Chemical Communications, 2013 , vol. 49, # 74 p. 8199 - 8201
反应条件
N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate in water; toluene
参考文献
US5948789 A1, ;
US 5948789 A
反应条件
N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate in water; toluene
参考文献
Astra Aktiebolag
Patent: US5948789 A1, 1999 ;
US 5948789 A
反应条件
hydrogen bromide in acetic acid
4 h; Ambient temperature;
参考文献
Mori, Kenji; Iwasawa, Hiroko
Tetrahedron, 1980 , vol. 36, # 1 p. 87 - 90
反应条件
hydrogen bromide
T=20°C; 16 h; Title compound not separated from byproducts;
参考文献
Chehade, Kareem A. H.; Baruch, Amos; Verhelst, Steven H. L.; Bogyo, Matthew
Synthesis, 2005 , # 2 art. no. M05904SS, p. 240 - 244
