4-(4-硝基苯氧基)四氢-1(2H)-吡啶羧酸叔丁酯合成路线 （共 10 条）
反应条件
potassium tert-butylate in dimethyl sulfoxide T=20°C; 2 h;
参考文献
CANCER THERAPEUTICS CRC PTY LIMITED; FOITZIK, Richard Charles; CHOI, Neil; MORROW, Benjamin Joseph; HEMLEY, Catherine Fae; LUNNISS, Gillian Elizabeth; CAMERINO, Michelle Ang; GANAME, Danny; STUPPLE, Paul Anthony; LESSENE, Romina; KERSTEN, Wilhelmus Johannes Antonius; HARVEY, Andrew John; HOLMES, Ian Peter
Patent: WO2014/26242 A1, 2014 ;
Location in patent: Page/Page column 153; 154 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu condensation; 21 h;
参考文献
Hirayama, Fukushi; Koshio, Hiroyuki; Katayama, Naoko; Kurihara, Hiroyuki; Taniuchi, Yuta; Sato, Kazuo; Hisamichi, Nami; Sakai-Moritani, Yumiko; Kawasaki, Tomihisa; Matsumoto, Yuzo; Yanagisawa, Isao
Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1509 - 1523
反应条件
in tetrahydrofuran; 4-hydroxy-piperidine; water; ethyl acetate
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6809088 B2, 2004 ;
反应条件
in hexane; N,N-dimethyl acetamide
参考文献
Sankyo Company, Limited
Patent: US6555556 B1, 2003 ;
US 6555556 B1
反应条件
hydrogenchloride; sodium hydrogencarbonate in ethanol; water
反应条件
triphenylphosphine in tetrahydrofuran; ethyl acetate; toluene
反应条件
1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C 2: potassium tert-butylate / dimethyl sulfoxide / 2 h / 20 °C View Scheme
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 4 h;
参考文献
Sankyo Company, Limited
Patent: EP1375482 A1, 2004 ;
Location in patent: Page 159 ;
反应条件
palladium in methanol; hexane
参考文献
Sankyo Company, Limited
Patent: US6555556 B1, 2003 ;
US 6555556 B1
反应条件
in 1,4-dioxane; diethyl ether
参考文献
G. D. Searle and Company
Patent: US6372758 B1, 2002 ;
US 6372758 B1
