4-氯-alpha-乙基苄醇合成路线 （共 30 条）
反应条件
1: ethyl bromide With iodine; magnesium in diethyl ether
Inert atmosphereReflux;
2: 4-chlorobenzaldehyde in diethyl ether
T=0°C; Inert atmosphere;
3: With water; ammonium chloride in diethyl ether
T=0°C; Inert atmosphere;
参考文献
Chang, Lu; Kuang, Yulong; Qin, Bo; Zhou, Xin; Liu, Xiaohua; Lin, Lili; Feng, Xiaoming
Organic Letters, 2010 , vol. 12, # 10 p. 2214 - 2217
反应条件
tetra-(n-butyl)ammonium iodide in tetrahydrofuran; N,N-dimethyl-formamide
9 h; Ambient temperatureelectrolysis with Pt/Cu electrodes;
参考文献
Choi, Jung Hoon; Youm, Jong Sung; Cho, Cheon-Gyu; Czae, Myung-Zoon; Hwang, Book Kee; Kim, Jung Sung
Tetrahedron Letters, 1998 , vol. 39, # 27 p. 4835 - 4838
反应条件
in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Fernandez-Mateos, Emilio; MacIa, Beatriz; Yus, Miguel
European Journal of Organic Chemistry, 2012 , # 20 p. 3732 - 3736
反应条件
[{(η6-C6Me6)Ru(μ-Cl)Cl}2]; water; sodium formate
T=100°C; 24 h; Inert atmosphere;
参考文献
Cadierno, Victorio; Crochet, Pascale; Francos, Javier; Garcia-Garrido, Sergio E.; Gimeno, Jose; Nebra, Noel
Green Chemistry, 2009 , vol. 11, # 12 p. 1992 - 2000
参考文献
Hu, Bin; Meng, Meng; Jiang, Shanshan; Deng, Weiping
Chinese Journal of Chemistry, 2012 , vol. 30, # 6 p. 1289 - 1294
参考文献
Meerwein et al.
Journal fuer Praktische Chemie (Leipzig), 1936 , vol. <2> 147, p. 226,239
反应条件
sodium hydrogen sulphate
T=160°C;
参考文献
Yueh, Wang; Bauld, Nathan L.
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 8 p. 529 - 538
反应条件
N,N-dichloro-p-toluenesulphonamide in acetonitrile
T=55°C; 8 h;
参考文献
Kim, Yong Hae; Lee, In Sang; Lim, Sang Chul
Chemistry Letters, 1990 , # 7 p. 1125 - 1128
参考文献
Palazzo,G. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, # 3 p. 447 - 456
反应条件
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux
2: acetic anhydride / 5 h / 80 °C / Inert atmosphere
View Scheme
参考文献
Hu, Bin; Meng, Meng; Jiang, Shanshan; Deng, Weiping
Chinese Journal of Chemistry, 2012 , vol. 30, # 6 p. 1289 - 1294
