(S)-N-Boc-2,2-二甲基噁唑烷-4-甲酸合成路线 （共 12 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 48 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=4;
参考文献
UCB PHARMA S.A.
Patent: WO2008/128919 A2, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/128919 A2
反应条件
toluene-4-sulfonic acid in N,N-dimethyl-formamide T=100°C;
参考文献
Lin, Chun-Chieh; Tantisantisom, Worawan; McAlpine, Shelli R.
Organic Letters, 2013 , vol. 15, # 14 p. 3574 - 3577
反应条件
1: BF3*Et2O / acetone / 2 h / 20 °C 2: aq. LiOH / methanol / 6 h / 0 - 20 °C View Scheme
参考文献
Hoffman, Robert V.; Tao, Junhua
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3953 - 3956
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 12 h / 20 °C 2: BF3*Et2O / acetone / 2 h / 20 °C 3: aq. LiOH / methanol / 6 h / 0 - 20 °C View Scheme
参考文献
Trajkovic, Milos; Ferjancic, Zorana; Saicic, Radomir N.
Tetrahedron Asymmetry, 2012 , vol. 23, # 8 p. 602 - 604
反应条件
1: With boron trifluoride diethyl etherate 2: With hydrogen; palladium on activated charcoal
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: WO2005/41899 A2, 2005 ;
Location in patent: Page/Page column 118 ;
WO 2005/041899 A2
反应条件
in methanol; hexane; benzene T=20°C; 1 h; Inert atmosphere;
参考文献
Lin, Chun-Chieh; Tantisantisom, Worawan; McAlpine, Shelli R.
Organic Letters, 2013 , vol. 15, # 14 p. 3574 - 3577
参考文献
Dondoni; Fantin; Fogagnolo; Medici
Journal of the Chemical Society - Series Chemical Communications, 1988 , # 1 p. 10 - 12
反应条件
1: diethyl ether 2: DIBAL-H / toluene / -70 °C View Scheme
参考文献
Trajkovic, Milos; Ferjancic, Zorana; Saicic, Radomir N.
Tetrahedron Asymmetry, 2012 , vol. 23, # 8 p. 602 - 604
反应条件
in methanol; hexane; benzene T=20°C; 1 h; Inert atmosphere;
参考文献
Lin, Chun-Chieh; Tantisantisom, Worawan; McAlpine, Shelli R.
Organic Letters, 2013 , vol. 15, # 14 p. 3574 - 3577
参考文献
Dondoni; Fantin; Fogagnolo; Medici
Journal of the Chemical Society - Series Chemical Communications, 1988 , # 1 p. 10 - 12
