16alpha-羟基泼尼松龙合成路线 （共 13 条）
1171-81-9(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-三羟基-17-(2-羟基乙酰基)-10,13-二甲基-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊并[a]菲-3-酮
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反应条件
mit Hilfe von Corynebacterium simplex oder Nocardia corallina;
参考文献
Journal of the American Chemical Society, , vol. 81, p. 1696,1699
反应条件
phosphoric acid T=0 - 5°C; 4 - 4.5 h; Product distribution / selectivity;
参考文献
Lenna, Roberto; Montoro, Maurizio
Patent: US2009/259037 A1, 2009 ;
Location in patent: Page/Page column 3-4 ;
反应条件
perchloric acid in 1,4-dioxane; water 0.166667 h; Product distribution / selectivity;
参考文献
Zhejiang Xianju Pharmaceutical Co., Ltd.
Patent: US2007/117974 A1, 2007 ;
Location in patent: Page/Page column 4 ;
反应条件
1: pyridine 2: SOCl2; pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol 5: CHCl3; HF 6: methanol.KOH 7: acetone; hydrochloric acid View Scheme
参考文献
Bernstein et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 1696,1699
反应条件
1: pyridine 2: SOCl2; pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol 5: CHCl3; HF View Scheme
参考文献
Bernstein et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 1696,1699
反应条件
perchloric acid; acetone
参考文献
Bernstein et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4573
反应条件
1: pyridine 2: SOCl2; pyridine 3: aqueous HClO4; dioxane 4: potassium acetate; ethanol 5: CHCl3; HF 6: methanol.KOH View Scheme
参考文献
Bernstein et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 1696,1699
反应条件
1: methanesulfonic acid / dichloromethane / 3.5 h / -20 °C 2: triphenylphosphine; N-bromosuccinmide / dichloromethane / 1 h / 10 - 16 °C / |Inert atmosphere 3: dimethyl sulfoxide / 1.5 h / 40 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PUDER, Carsten; MERTEN, Joern; SCHMITT, Heinz-Peter; THUMERER, Markus; WEYELL, Bjoern
Patent: WO2013/124395 A1, 2013 ;
反应条件
1: perchloric acid / dichloromethane; acetonitrile / 0 - 5 °C 2: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C View Scheme
参考文献
Cipla Limited
Patent: EP2392584 A1, 2011 ;
反应条件
perchloric acid in dichloromethane T=0 - 5°C; 6 h;
参考文献
Cipla Limited
Patent: EP2392584 A1, 2011 ;
Location in patent: Page/Page column 12 ;
