3,5-二氯吡啶-4-羧酸合成路线 （共 10 条）
反应条件
1: 3,5-dichloro-pyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: carbon dioxide
参考文献
Palani, Anandan; Shapiro, Sherry; Clader, John W.; Greenlee, William J.; Vice, Susan; McCombie, Stuart; Cox, Kathleen; Strizki, Julie; Baroudy, Bahige M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 709 - 712
反应条件
CO2; diisopropylamine in tetrahydrofuran
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; sodium hydroxide; hexane
反应条件
thionyl chloride T=180 - 220°C; im Rohr und Zersetzen des Reaktionsprodukts mit Wasser;
参考文献
Chemische Berichte, , vol. 61, p. 2214
反应条件
phosphorus; hydrogen iodide
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 148, p. 13,16
反应条件
T=180 - 220°C; im Rohr und nachfolgend Zersetzen mit Wasser;
参考文献
Chemische Berichte, , vol. 61, p. 2214
反应条件
1: With thionyl chloride 18 h; Heating / reflux; 2: in 1,4-dioxane T=0 - 20°C; 1 h; 3: With thionyl chloride 1 h; Heating / reflux;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2004/92170 A2, 2004 ;
Location in patent: Page 23; 24 ;
WO 2004/092170 A2
参考文献
Meyer; Graf
Chemische Berichte, 1928 , vol. 61, p. 2214
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in benzene
T=20°C;
2: With hydroxylamine in diethylene glycol dimethyl ether; water
参考文献
Dai, Yujia; Hartandi, Kresna; Michaelides, Michael R.
Patent: US2006/178378 A1, 2006 ;
Location in patent: Page/Page column 16 ;
US 20060178378 A1
反应条件
hydrogen fluoride; 3-chloro-benzenecarboperoxoic acid in methanol; N,N-dimethyl-formamide
参考文献
Palani, Anandan; Shapiro, Sherry; Clader, John W.; Greenlee, William J.; Vice, Susan; McCombie, Stuart; Cox, Kathleen; Strizki, Julie; Baroudy, Bahige M.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 4 p. 709 - 712
