4-苯基-5,5-二乙氧羰基-2-吡咯烷酮合成路线 （共 3 条）
反应条件
sodium ethanolate 1.) EtOH, RT, 2.) EtOH, reflux, 24 h; Yield given. Multistep reaction;
参考文献
Bayer Aktiengesellschaft; Chinese Academy of Medical Sciences
Patent: US4731456 A1, 1988 ;
参考文献
Xue, Jian Jun; Zhou, Yu Mei; Yu, Xiao Ming
Chinese Chemical Letters, 2011 , vol. 22, # 11 p. 1261 - 1264
反应条件
1: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 1 h 2: aq. Ba(OH)2 / ethanol / 0.33 h / 70 °C 3: 170 °C 4: 89.2 percent / LiB(Et)3H / tetrahydrofuran / 1 h / 0 °C 5: trifluoroacetic anhydride, DMSO / CH2Cl2 / 1.5 h / -60 °C 6: tetrahydrofuran / 1 h / 0 - 5 °C 7: trifluoroacetic anhydride, DMSO / CH2Cl2 / 1.5 h / -60 °C 8: LiB(Et)3H / tetrahydrofuran / 1 h / 0 °C 9: 1.) LDA, HMPT, 2.) P(OEt)3, O2 / 1.) THF, hexane, from -70 to -60 deg C, 1 h, 2.) THF, hexane, -70 deg C View Scheme
参考文献
Hartwig, Wolfgang; Born, Liborius
Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4352 - 4358
