2-(4-甲氧基苯基)-1H-吡咯并[2,3-b]吡啶合成路线 （共 5 条）
反应条件
1: 3-Methylpyridine With lithium diisopropyl amide
T=0°C; 0.5 h;
2: 2-methoxy 5-cyanobenzene T=0 - 15°C;
3: With lithium diisopropyl amide
T=0°C; Reflux;
参考文献
Selig, Roland; Schollmeyer, Dieter; Albrecht, Wolfgang; Laufer, Stefan
Tetrahedron, 2011 , vol. 67, # 47 p. 9204 - 9213
反应条件
1: 1-(4-methoxyphenyl)ethanone With allyl(1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene)palladium(IV) chloride; sodium hexamethyldisilazane in tetrahydrofuran
T=20°C; 0.0833333 h; Inert atmosphere;
2: 2-Amino-3-bromopyridine in tetrahydrofuran
T=20 - 105°C; 4 h; Inert atmosphere; regioselective reaction;
参考文献
Spergel, Steven H.; Okoro, Danielle R.; Pitts, William
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5316 - 5319
反应条件
1: 2-picoline With lithium diisopropyl amide in tetrahydrofuran
T=-40°C; 0.5 h;
2: 2-methoxy 5-cyanobenzene in tetrahydrofuran
T=-40 - 20°C; Further stages.;
参考文献
Mettey, Yvette; Gompel, Marie; Thomas, Virginie; Garnier, Matthieu; Leost, Maryse; Ceballos-Picot, Irene; Noble, Martin; Endicott, Jane; Vierfond, Jean-Michel; Meijer, Laurent
Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 222 - 236
反应条件
1: With trifluoroacetic acid in acetonitrile
1 h; Heating;
2: With sodium hydroxide in water; acetonitrile
T=20°C; Further stages.;
参考文献
Parcerisa, Javier; Romero, Manel; Pujol, Maria Dolors
Tetrahedron, 2008 , vol. 64, # 3 p. 500 - 507
反应条件
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 70 °C / |Inert atmosphere
2: trifluoroacetic acid; trifluoroacetic anhydride / acetonitrile / 8 h / 100 °C
View Scheme
参考文献
Leboho, Tlabo C.; Van Vuuren, Sandy F.; Michael, Joseph P.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 307 - 315
