sodium hydroxide; chloramine-T; acetic acid 1.) THF-water, 70 deg C, 30 min, 2.) ambient temperature, 30 min; Yield given. Multistep reaction;

potassium acetate; palladium diacetate in N,N-dimethyl-formamide T=20 - 85°C; Inert atmosphere;

n-butyllithium in tetrahydrofuran; hexane Addn. of butyl-lithium in hexane to a stirred soln. of CH3SC4H2N2Br in THF under N2 at -95°C followed by stirring for 60 min at -85°C, addn. of (CH3)3SnCl at -90°C, stirring for 30 min at -85°C and 20 h at 0°C.; Pouring into aq. ammonium chloride, stirring 10 min, sepn. of two phases, extn. of aq. phase with chloroform, washing the org. phases, drying (MgSO4), evapn., flash chromy. (silica gel; light petroleum-EtOAc), elem. anal.;

methanol; chloramine-T in acetic acid T=50°C; 2 h;

chloramine-T in acetic acid T=50°C; 2 h;

bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran addn. of Bu4NF in THF to mixture of pyrimidine deriv., Bu6Sn2 and Pd-catalyst (N2-stream); stirring at ambiente temp. for 4h; GLC-monitoring; addn. of EtOAc; washing (water); flash chromy. (silica; hexane/EtOAc 1:1); distn.;

in tetrahydrofuran addn. of pyrimidine deriv. in THF to stannyl-THF soln. at -78°C while stirring (N2); after 10h quenching with NH4Cl soln.; extn. (EtOAc); washing, drying; flash chromy. (silica; hexane/EtOAc 1:1); distn.;

in tetrahydrofuran addn. of pyrimidine deriv. in THF to stannyl-THF soln. at -78°C while stirring (N2); after 10h quenching with NH4Cl soln.; extn. (EtOAc); washing, drying; flash chromy. (silica; hexane/EtOAc 1:1); distn.;

3-chloro-benzenecarboperoxoic acid in chloroform

N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium in tetrahydrofuran; hexane 1.) -85 deg C, 30 min, 2.) 0 deg C, 20 h;