1: (5aR,8aS,11aR,11bS)-2-acetoxy-5,5a,9,10-tetrahydro-6,11b-ethano-7Hfuro[2',3',4',5':4,5]phenanthro[9,8a-d]oxazol-11(11aH)-one With methanol; chloro-trimethyl-silane T=20°C; 2 h; 2: vinyl-magnesium bromide in tetrahydrofuran T=0 - 20°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; water T=60°C; pH=1.5; 2 h;

1: ammonia; acetic acid / 18 h / 20 - 50 °C / pH 9 2: triethylamine / 1-methyl-pyrrolidin-2-one; water / 9.5 h / 70 °C / Inert atmosphere View Scheme

ammonia; acetic acid T=20 - 50°C; pH=9; 18 h; Product distribution / selectivity;

1: ammonia; acetic acid / 18 h / 20 - 50 °C / pH 9 2: triethylamine / 1-methyl-pyrrolidin-2-one; water / 8 h / 70 °C / Inert atmosphere View Scheme