2-(2,4-二氟苯基)-2-丙烯-1-醇合成路线 （共 7 条）
反应条件
potassium hydroxide in 1,4-dioxane; water
参考文献
US5703079 A1, ;
US5661151 A1, ;
反应条件
Rongalit; sodium hydroxide in 1,4-dioxane T=55 - 60°C; 0.5 h; Inert atmosphere;
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 2: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 31, # 9 p. 1139 - 1143
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C 1.2: 0.5 h 2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 3.1: Rongalit; sodium hydroxide / 1,4-dioxane / 0.5 h / 55 - 60 °C / |Inert atmosphere View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 31, # 9 p. 1139 - 1143
反应条件
in diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
SCHERING CORPORATION
Patent: EP539938 A1, 1993 ;
反应条件
1: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; tert.-butylhydroperoxide / dichloromethane; n-heptane / 8 h / -20 °C / |Inert atmosphere 2: potassium carbonate / tetrahydrofuran / 48 h / |Reflux View Scheme
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
反应条件
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate in n-heptane; dichloromethane T=-20°C; Sharpless Asymmetric Epoxidation; 8 h; Inert atmosphere; Overall yield = 44 percent; Overall yield = 4.7 g;
参考文献
Zhang, Yongqiang; Wang, Shengzheng; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian; Sheng, Chunquan
Chinese Journal of Chemistry, 2013 , vol. 31, # 9 p. 1139 - 1143
