4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride in methanol; water T=20°C; 0.5 h;

Yield given. Multistep reaction;

1: 1.) NaOMe; 2.) Et3N / 1.) MeOH, r.t., 10 min; 2.) MeOH, r.t., 3 h 2: pyridine 3: 82 percent / 33percent hydrobromic acid / CH2Cl2; acetic acid / 0.5 h / 0 °C 4: 87 percent / acetic acid / 0.75 h / Ambient temperature 5: 95 percent / 5 Angstroem molecular sieves / trimethylsilyl triflate / CH2Cl2 / 12 h / -35 °C 6: dimethyl malonate / Pd(PPh3)4 / tetrahydrofuran / 24 h / Ambient temperature 7: pyridine View Scheme