3-二氟甲基-1-甲基吡唑-4-甲酸乙酯合成路线 （共 42 条）
反应条件
N,N-dimethyl acetamide T=20 - 160°C;
参考文献
WO2012/19950 A1, ;
Page/Page column 20-21 ;
反应条件
N,N-dimethyl-formamide T=20 - 160°C;
参考文献
WO2012/19950 A1, ;
Page/Page column 20 ;
反应条件
triethylamine; triphenylphosphine; tris-triphenylphosphine palladium (II) chloride T=150°C; P=4500.45 - 5250.53 Torr; Product distribution / selectivity;
参考文献
EP2008996 A1, ;
Page/Page column 13 ;
反应条件
methanesulfonic acid T=160°C; 7 h; Autoclave;
参考文献
WO2011/12618 A2, ;
Page/Page column 24 ;
反应条件
triethylamine tris(hydrogen fluoride) T=145°C; 8 h; Neat (no solvent);
参考文献
WO2005/44804 A1, ;
Page/Page column 10 ;
反应条件
1: With sodium hydride in diethyl ether T=20°C; 0.5 h; 2: With cis amino chloride in diethyl ether T=-15°C; 1 h; 3: With cis amino chloride; sodium hydride in tetrahydrofuran; diethyl ether T=20°C; Product distribution / selectivity;
参考文献
EP2008996 A1, ;
Page/Page column 17-18 ;
反应条件
toluene-4-sulfonic acid in ethanol T=25 - 50°C; 16 h; Inert atmosphere; Product distribution / selectivity;
参考文献
US2011/172436 A1, ;
Page/Page column 11 ;
反应条件
1: ethyl 2-ethoxymethylidene-3-oxo-3-trifluoromethylpropionate With chloro-trimethyl-silane; magnesium in N,N-dimethyl-formamide T=0 - 10°C; Cooling with ice; 2: methylhydrazine in ethanol; water; N,N-dimethyl-formamide T=-50 - 20°C; Product distribution / selectivity;
参考文献
US2010/69646 A1, ;
Page/Page column 8-9 ;
反应条件
1: (Z)-ethyl 2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoate With hydrazine hydrate in toluene T=15 - 20°C; 2.5 h; 2: dimethyl sulfate With anhydrous tetramethylammonium chloride; sodium hydroxide in water; toluene T=20°C; pH=10.5 - 12; 4 h; Product distribution / selectivity;
参考文献
WO2011/12620 A2, ;
Page/Page column 18 ;
反应条件
triethylamine tris(hydrogen fluoride) T=120°C; 8 h; Neat (no solvent);
参考文献
WO2005/44804 A1, ;
Page/Page column 10 ;
