1: pyridinium chlorochromate / dichloromethane / 4 h / 0 °C / |Inert atmosphere 2: MgBr2(Et2O) / diethyl ether / 2 h / 20 °C 3: sodium hydroxide; DCN; biphenyl / acetonitrile; water / 6 h / 20 °C / |Inert atmosphere; |UV-irradiation View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1.1: pyridine / N,N-dimethyl-formamide / 0 - 20 &deg;C / |Inert atmosphere<br />2.1: pyridinium chlorochromate / dichloromethane / 4 h / 0 &deg;C / |Inert atmosphere<br />3.1: tetrahydrofuran / 0 &deg;C / |Inert atmosphere<br />3.2: |Inert atmosphere<br /> <br /> &nbsp;

Stage #1: &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0&deg;C;&nbsp;Grignard Reaction;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4371014', constants.ctx, '0')">ammonium chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />Grignard Reaction;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;