1,2-环己烷二酮[(4-氯苯基)肼酮]合成路线 （共 6 条）
反应条件
1: 4-chloro-aniline With hydrogenchloride; sodium nitrite in water T=0°C; 0.833333 h; 2: 2-hydroxymethylidenecyclohexanone With sodium acetate in methanol; water T=0°C; 0.583333 h;
参考文献
WO2004/110999 A1, ;
Page 27-28 ;
反应条件
1: 4-amino-phenol With hydrogenchloride; sodium nitrite in water T=0°C; 0.833333 h; 2: 2-hydroxymethylidenecyclohexanone With sodium acetate in methanol; water 0.5 - 0.583333 h;
参考文献
WO2005/5386 A1, ;
Page 27-28 ;
反应条件
in isopropyl alcohol T=20°C; 3 h;
参考文献
Journal of the Chinese Chemical Society, , vol. 48, # 2 p. 215 - 228
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 9 p. 2942 - 2955
反应条件
sodium acetate in methanol; water
参考文献
Journal of Heterocyclic Chemistry, , vol. 48, # 2 p. 331 - 338
反应条件
hydrogenchloride in acetic acid T=120°C; 0.333333 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/110999 A1, 2004 ;
Location in patent: Page 28 ;
