R(-)-4-氰基-3-羟基丁酸乙酯合成路线 （共 24 条）
反应条件
ammonia; nickel dichloride in aq. phosphate buffer; water T=30°C; pH=8; Enzymatic reaction; Kinetics;
参考文献
ChemBioChem, , vol. 14, # 7 p. 870 - 881
反应条件
platinum(IV) oxide; hydrogen in methanol
参考文献
Scarpi, Dina; Avataneo, Ottavia; Prandi, Cristina; Venturello, Paolo; Occhiato, Ernesto G.
Synthesis (Germany), 2012 , vol. 44, # 23 art. no. SS-2012-Z0642-OP, p. 3688 - 3692
反应条件
1: hexane; tetrahydrofuran 2: NaBH4, B(Et)2OMe / methanol / -90 °C 3: MeSO3H View Scheme
参考文献
Brower; Butler; Deering; Le; Millar; Nanninga; Roth
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2279 - 2282
反应条件
1: acetic acid tert-butyl ester With ammonia; lithium; isoprene in tert-butyl methyl ether T=-58 - -48°C; Claisen Condensation; 5 h; 2: ethyl (R)-3-hydroxy-4-cyano-butyrate T=-45 - 20°C; Claisen Condensation;
参考文献
BAKHU PHARMA LIMITED; LEECE, Colin; PROCTOR, Lee David
Patent: WO2014/13261 A1, 2014 ;
Location in patent: Page/Page column 12 ;
