2-氨基-1,9-二氢-9-[(1S,3R,4S)-4-苄氧基-3-苄氧基甲基-2-亚甲基环戊基]-6H-嘌呤-6-酮合成路线 （共 12 条）
反应条件
hydrogenchloride in tetrahydrofuran; methanol T=55°C;
参考文献
Bisacchi; Chao; Bachard; Daris; Innaimo; Jacobs; Kocy; Lapointe; Martel; Merchant; Slusarchyk; Sundeen; Young; Colonno; Zahler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 2 p. 127 - 132
反应条件
1: tetrahydrofuran / -78 - -65 °C 2: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C 3: VO(acac)2, t-BuOOH / CH2Cl2 4: NaH, Bu4NI / dimethylformamide 5: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 6: 82 percent / TEA, DMAP / CH2Cl2 7: Dess-Martin reagent, t-BuOH / CH2Cl2 8: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 9: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C 2: VO(acac)2, t-BuOOH / CH2Cl2 3: NaH, Bu4NI / dimethylformamide 4: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 5: 82 percent / TEA, DMAP / CH2Cl2 6: Dess-Martin reagent, t-BuOH / CH2Cl2 7: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 8: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 2: 82 percent / TEA, DMAP / CH2Cl2 3: Dess-Martin reagent, t-BuOH / CH2Cl2 4: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 5: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: NaH, Bu4NI / dimethylformamide 2: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 3: 82 percent / TEA, DMAP / CH2Cl2 4: Dess-Martin reagent, t-BuOH / CH2Cl2 5: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 6: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: VO(acac)2, t-BuOOH / CH2Cl2 2: NaH, Bu4NI / dimethylformamide 3: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 4: 82 percent / TEA, DMAP / CH2Cl2 5: Dess-Martin reagent, t-BuOH / CH2Cl2 6: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 7: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: Dess-Martin reagent, t-BuOH / CH2Cl2 2: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 3: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 2: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: 82 percent / TEA, DMAP / CH2Cl2 2: Dess-Martin reagent, t-BuOH / CH2Cl2 3: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 4: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
反应条件
1: tetrahydrofuran / -78 - -65 °C 2: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C 3: VO(acac)2, t-BuOOH / CH2Cl2 4: NaH, Bu4NI / dimethylformamide 5: 60 percent / LiH / dimethylformamide / 2 h / 125 °C 6: 82 percent / TEA, DMAP / CH2Cl2 7: Dess-Martin reagent, t-BuOH / CH2Cl2 8: Zn, TiCl4 / tetrahydrofuran; CH2Cl2 9: 92 percent / aq. HCl / tetrahydrofuran; methanol / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 2 p. 127 - 132
