2′-羟基-5′-溴苯乙酮合成路线 （共 81 条）
反应条件
trifluoroacetic acid in acetone; benzene
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
反应条件
hydrogenchloride in acetone; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
bromine; acetic acid
参考文献
Petit, Laurent; Zard, Samir Z.
Chemical Communications, 2010 , vol. 46, # 28 p. 5148 - 5150
反应条件
1: 5'-bromo-2'-hydroxyacetophenone With pyrrolidine in methanol 2: tert-butyl 4-oxo-piperidine-1-carboxylate in methanol T=80°C;
参考文献
CEPHALON, INC.; PHARMACOPEIA, INC.
Patent: WO2009/97567 A1, 2009 ;
Location in patent: Page/Page column 62 ;
WO 2009/097567 A1
反应条件
sodium ethanolate in ethanol 2 h; Reflux;
参考文献
Jana, Ranjan; Partridge, James J.; Tunge, Jon A.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5157 - 5161
反应条件
1: potassium carbonate / butanone / 16 h / 80 °C 2: sodium hydride / tetrahydrofuran; mineral oil / 20 h / 20 °C / Reflux View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; THOMPSON III, Lorin A.; SHI, Jianliang; WU, Yong-Jin; MARCIN, Lawrence R.; RAJAMANI, Ramkumar; HIGGINS, Mendi A.
Patent: WO2012/162330 A1, 2012 ;
反应条件
methanecarbohydroxamic acid; sulfuric acid in acetonitrile T=80°C; P=1292.9 Torr; 0.166667 h; Microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 52, # 46 p. 6103 - 6107
反应条件
nitric acid in tetrachloromethane
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
pyrrolidine in methanol T=70°C; 4 h; Microwave irradiation;
参考文献
DAC S.R.L.; VARASI, Mario; THALER, Florian; AMICI, Raffaella; ABATE, Agnese; FULCO, Maria Carmela; MINUCCI, Saverio; MERCURIO, Ciro
Patent: WO2011/45265 A2, 2011 ;
Location in patent: Page/Page column 26 ;
WO 2011/045265 A1
反应条件
1: pyrrolidine / methanol / 25 °C 2: NaBH4 / methanol / 0 - 20 °C View Scheme
参考文献
Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034
