2-甲基-2-硫代异脲硫酸盐合成路线 （共 127 条）
反应条件
sodium acetate in N,N-dimethyl-formamide
T=80 - 90°C; 12 h;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: S-methylisothiourea sulfate; ethyl 3-oxo-3-phenylpropionate; isobutyraldehyde With sodium hydrogencarbonate in N,N-dimethyl-formamide
T=75°C; Biginelli three-component-coupling;
2: tert.-butylhydroperoxide With potassium carbonate; copper dichloride in dichloromethane; water
T=38 - 40°C;
参考文献
Yamamoto, Kana; Chen, Ye Grace; Buono, Frederic G.
Organic Letters, 2005 , vol. 7, # 21 p. 4673 - 4676
反应条件
1: S-methylisothiourea sulfate With potassium hydroxide in methanol
T=20°C; 0.166667 h;
2: 1-bromo-2-phenoxyethane in methanol
0.5 h;
参考文献
Shevchenko, Nikolay E.; Nenajdenko, Valentine G.; Balenkova, Elizabeth S.
Synthesis, 2003 , # 8 p. 1191 - 1200
反应条件
sodium hydroxide; acetic acid in methanol; water
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4145431 A1, 1979 ;
反应条件
ethanol; sodium ethanolate
Cyclization; Condensation; 2 h;
参考文献
Wang, Jiang-Hong; Shen, Yu-Quan; Yu, Cong-Xuan; Si, Jing-Hai
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1455 - 1460
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
反应条件
(i) K2CO3, MeCOEt, (ii) LiAlH4, Et2O, (iii) /BRN= 3572707/; Multistep reaction;
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
