6-氰基-2-萘基三氟甲烷磺酸酯合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=0 - 20°C; 48 h;
参考文献
Yamaji, Minoru; Maeda, Hajime; Minamida, Keita; Maeda, Tomohiro; Asai, Kengo; Konishi, Gen-Ichi; Mizuno, Kazuhiko
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 321 - 345
反应条件
pyridine; hydrogenchloride; trifluoromethylsulfonic anhydride in hexane; ethyl acetate
参考文献
Array Biopharma Inc.
Patent: US6221914 B1, 2001 ;
US 6221914 B1
反应条件
potassium carbonate in tetrahydrofuran T=120°C; 0.133333 h; Microwave irradiation;
参考文献
Heim, Ralf; Lucas, Simon; Grombein, Cornelia M.; Ries, Christina; Schewe, Katarzyna E.; Negri, Matthias; Mueller-Vieira, Ursula; Birk, Barbara; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 5064 - 5074
反应条件
1: 1,3-dimethyl-2-imidazolidione / 3 h / 160 °C 2: 72 percent / pyridine / 15 h / 23 °C View Scheme
参考文献
Yamaji, Minoru; Maeda, Hajime; Minamida, Keita; Maeda, Tomohiro; Asai, Kengo; Konishi, Gen-Ichi; Mizuno, Kazuhiko
Research on Chemical Intermediates, 2013 , vol. 39, # 1 p. 321 - 345
参考文献
Seed; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2000 , vol. 10, # 9 p. 2069 - 2080
反应条件
1: 83 percent / Pd(OAc)2; PPh3; Et3N / dimethylformamide / 4 h / 65 °C
2: 34 percent / LiI; NaCN / dimethylformamide / 19 h / 140 °C
View Scheme
参考文献
Ono, Shin'ichiro; Inoue, Yoshihisa; Yoshida, Tomohiro; Ashimori, Atsuyuki; Kosaka, Keigo; Imada, Teruaki; Fukaya, Chikara; Nakamura, Norifumi
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 12 p. 1685 - 1693
