1: 2-bromo-pyridine; tributyltin chloride With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: 2,5-dibromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C;
1: 5-Bromo-2-methyl-pyridine With n-butyllithium in diethyl ether; hexane T=-78°C; 1 h; 2: tributyltin chloride in diethyl ether; hexane T=-78 - 0°C; 1 h; 3: With water; ammonium chloride in diethyl ether; hexane
参考文献
DeGoey, David A.; Flentge, Charles A.; Flosi, William J.; Grampovnik, David J.; Kempf, Dale J.; Klein, Larry L.
Patent: US2005/131017 A1, 2005 ;
Location in patent: Page/Page column 136 ;
in tetrahydrofuran Electrolysis; electrolysis carried out galvanostatically at 25-28°C in an atm.of dry N2, electrolyte 0.4 M LiClO4/THF; hexane added to electrolyte, ppt. filtered off, filtrate analyzed for product by GC, Bu3SnSiMe3 isolated in pure by chromy.;
