N-(4-甲氧基亚苄基)-4-甲基苯磺酰胺合成路线 （共 33 条）
反应条件
1: tetrahydrofuran / -50 - 20 °C / |Inert atmosphere
2: caesium carbonate / acetone; toluene / 20 °C
3: Au(Ph3P)+NTf2- / dichloromethane / 6 h / 40 °C
View Scheme
参考文献
Hashmi, A. Stephen K.; Haeffner, Tobias; Yang, Weibo; Pankajakshan, Sreekumar; Schaefer, Sascha; Schultes, Lara; Rominger, Frank; Frey, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 34 p. 10480 - 10486
反应条件
in dimethyl sulfoxide
T=100°C; 12 h; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Fang, Fan; Li, Yuan; Tian, Shi-Kai
European Journal of Organic Chemistry, 2011 , # 6 p. 1084 - 1091
反应条件
FeCl3·6H2O in dichloromethane
T=0 - 20°C; Friedel Crafts arylation; 2 h; Inert atmosphere;
参考文献
Thirupathi, Ponnaboina; Soo Kim, Sung
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5240 - 5249
反应条件
in tetrahydrofuran; diethyl ether
T=20°C; Grignard addition; 12 h;
参考文献
Prasad, B. A. Bhanu; Bisai, Alakesh; Singh, Vinod K.
Organic Letters, 2004 , vol. 6, # 26 p. 4829 - 4831
反应条件
in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Candito, David A.; Lautens, Mark
Synlett, 2011 , # 14 art. no. S04911ST, p. 1987 - 1992
反应条件
1.1: 91 percent / tetrahydrofuran; diethyl ether / 12 h / 20 °C
2.1: BH3*DMS / tetrahydrofuran / 12 h / 20 °C
2.2: aq. NaOH; aq. H2O2; EtOH / tetrahydrofuran / 2 h / 20 °C
2.3: 71 percent / DIAD; PPh3 / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Ghorai, Manas K.; Das, Kalpataru; Kumar, Amit; Das, Animesh
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5393 - 5397
反应条件
FeCl3·6H2O in dichloromethane
T=20°C; Friedel Crafts arylation; 2 h; Inert atmosphere;
参考文献
Thirupathi, Ponnaboina; Soo Kim, Sung
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5240 - 5249
反应条件
in toluene
T=120°C; 12 h; Inert atmosphere; optical yield given as percent de;
参考文献
Yan, Yizhe; Xu, Kun; Fang, Yang; Wang, Zhiyong
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6849 - 6855
反应条件
1: tetrahydrofuran / -50 - 20 °C / |Inert atmosphere
2: caesium carbonate / acetone; toluene / 20 °C
3: Au(Ph3P)+NTf2- / dichloromethane / 0.17 h / 20 °C
View Scheme
参考文献
Hashmi, A. Stephen K.; Haeffner, Tobias; Yang, Weibo; Pankajakshan, Sreekumar; Schaefer, Sascha; Schultes, Lara; Rominger, Frank; Frey, Wolfgang
Chemistry - A European Journal, 2012 , vol. 18, # 34 p. 10480 - 10486
反应条件
potassium tert-butylate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride in tetrahydrofuran
T=0°C; Strecker reaction; 5 h;
参考文献
Fukuda, Yoshimasa; Maeda, Yuka; Kondo, Kazuhiro; Aoyama, Toyohiko
Synthesis, 2006 , # 12 p. 1937 - 1939
