(S)-3-甲基-1-[2-(1-哌啶基)苯基]丁胺合成路线 （共 19 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in water T=50°C; P=3750.3 Torr; 5 h; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 68.9 g / NaBH4 / methanol / 10 - 15 °C 2: N-acetyl-L-glutamic acid / acetone View Scheme
参考文献
Chimia, , vol. 60, # 9 p. 593 - 597
反应条件
ammonia in hydrogenchloride
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal T=50°C; P=3750.3 Torr; 5 h; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal T=50°C; P=3750.3 Torr; 10 h; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C 2: tetrahydrofuran; toluene / 3 h / Heating 3: 34 percent / toluene / 15 h / Ambient temperature 4: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr 5: aq. HCl / 5.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: tetrahydrofuran; toluene / 3 h / Heating 2: 34 percent / toluene / 15 h / Ambient temperature 3: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr 4: aq. HCl / 5.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C 2: tetrahydrofuran; toluene / 3 h / Heating 3: 34 percent / toluene / 15 h / Ambient temperature 4: H2, NaOH, Et3N, Ti(OiPr)4 / Ru(OAc)2<(S)-BINAP> / methanol; CH2Cl2 / 170 h / 30 °C / 75006 Torr 5: aq. HCl / 5.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: Ambient temperature 2: Ti(OiPr)4 / tetrahydrofuran; toluene / 60 h / 100 °C 3: H2, aq. HCl / 10 percent Pd/C / 5 h / 50 °C / 3750.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
反应条件
1: 63 percent / Et3N, TiCl4 / toluene / Ambient temperature 2: 76 percent / H2, Ti(O-iPr)4 / Raney-Ni / ethanol / 72 h / 50 °C / 150012 Torr 3: H2, aq. HCl / 10 percent Pd/C / H2O / 5 h / 50 °C / 3750.3 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 26 p. 5219 - 5246
