2-氟-3-氧代-3-苯丙酸乙酯合成路线 （共 18 条）
反应条件
1: 44 percent / sodium borohydride / ethanol / 5 h / -78 - 20 °C 2: DIBAL / tetrahydrofuran; toluene / 20 °C 3: H2 / chiral iridium catalyst / CH2Cl2 / 24 h / 20 °C / 15001.2 Torr View Scheme
参考文献
Engman, Mattias; Diesen, Jarle S.; Paptchikhine, Alexander; Andersson, Pher G.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4536 - 4537
反应条件
1: 44 percent / sodium borohydride / ethanol / 5 h / -78 - 20 °C 2: DIBAL / tetrahydrofuran; toluene / 20 °C 3: 48 percent / pyridine / 24 h / 20 °C 4: H2 / chiral Iridium catalyst / CH2Cl2 / 12 h / 20 °C / 22501.8 Torr View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 15 p. 4536 - 4537
反应条件
iodosylbenzene; hydrogen fluoride in dichloromethane; water
T=40°C; 24 h;
参考文献
Kitamura, Tsugio; Kuriki, Satoshi; Muta, Kensuke; Morshed, Mohammad Hasan; Muta, Kazutaka; Gondo, Keisuke; Hori, Yuji; Miyazaki, Masaya
Synthesis (Germany), 2013 , vol. 45, # 22 art. no. SS-2013-F0521-OP, p. 3125 - 3130
反应条件
Selectfluorreg;; (η5-C5H5)titanium trichloride in acetonitrile
T=20°C;
参考文献
Frantz, Richard; Hintermann, Lukas; Perseghini, Mauro; Broggini, Diego; Togni, Antonio
Organic Letters, 2003 , vol. 5, # 10 p. 1709 - 1712
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran
T=0°C; 1 h;
2: benzoyl chloride in tetrahydrofuran
T=20°C; 4 h;
参考文献
Engman, Mattias; Diesen, Jarle S.; Paptchikhine, Alexander; Andersson, Pher G.
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4536 - 4537
反应条件
1: [bis(acetoxy)iodo]benzene With hydrogen fluoride in dichloromethane; water
T=20°C; 0.25 h;
2: ethyl 3-oxo-3-phenylpropionate in dichloromethane; water
T=40°C; 24 h;
参考文献
Kitamura, Tsugio; Kuriki, Satoshi; Muta, Kensuke; Morshed, Mohammad Hasan; Muta, Kazutaka; Gondo, Keisuke; Hori, Yuji; Miyazaki, Masaya
Synthesis (Germany), 2013 , vol. 45, # 22 art. no. SS-2013-F0521-OP, p. 3125 - 3130
反应条件
hydrogen fluoride; bis-[(trifluoroacetoxy)iodo]benzene in dichloromethane; water
T=40°C; 24 h;
参考文献
Kitamura, Tsugio; Kuriki, Satoshi; Muta, Kensuke; Morshed, Mohammad Hasan; Muta, Kazutaka; Gondo, Keisuke; Hori, Yuji; Miyazaki, Masaya
Synthesis (Germany), 2013 , vol. 45, # 22 art. no. SS-2013-F0521-OP, p. 3125 - 3130
反应条件
HBF4*Et2O in dichloromethane
T=0 - 20°C; 5 h; Inert atmosphere; Reagent/catalystSolventTemperatureTime;
参考文献
Pasceri, Raffaele; Bartrum, Hannah E.; Hayes, Christopher J.; Moody, Christopher J.
Chemical Communications, 2012 , vol. 48, # 99 p. 12077 - 12079
反应条件
silica gel in water; ethyl acetate
T=40°C; 24 h; Yield given;
参考文献
Kim; Rhie; Oh
Tetrahedron Letters, 1996 , vol. 37, # 5 p. 653 - 654
参考文献
The Upjohn Company
Patent: US4795812 A1, 1989 ;
