(2-氟苯甲酰)乙酸乙酯合成路线 （共 16 条）
反应条件
1: in tetrahydrofuran T=0 - 25°C; 46 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20 - 25°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1471056 A1, 2004 ;
Location in patent: Page 45-46 ;
反应条件
sodium hydride in toluene; mineral oil
参考文献
Chen, Yi-Fong; Lin, Yi-Chien; Huang, Po-Kai; Chan, Hsu-Chin; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5064 - 5075
参考文献
Li, Sai; Jiang, Rui; Qin, Mingze; Liu, Haicheng; Zhang, Guangyan; Gong, Ping
Archiv der Pharmazie, 2013 , vol. 346, # 7 p. 521 - 533
反应条件
1: propanedioic acid monoethyl ester With [2,2']bipyridinyl; n-butyllithium in tetrahydrofuran T=-78 - -5°C; Inert atmosphere; 2: 2-fluoro-benzoyl chloride in tetrahydrofuran T=-78 - -30°C; Inert atmosphere;
参考文献
Bunce, Richard A.; Lee, Eric J.; Grant, Matthew T.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 620 - 625
反应条件
1: thionyl chloride / toluene / 8 h / 80 °C 2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 6 h / 0 °C 3: 5 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 11 p. 2843 - 2855
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 6 h / 0 °C 2: 5 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 11 p. 2843 - 2855
反应条件
1: potassium tert-butylate / neat (no solvent) / 0.5 h / 20 °C 2: bis-triphenylphosphine-palladium(II) chloride / neat (no solvent) / 5 h / 20 °C View Scheme
参考文献
RSC Advances, , vol. 3, # 31 p. 12616 - 12620
反应条件
in toluene T=90°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 20 p. 9349 - 9358
反应条件
sulfuric acid 1.) C6H6; 2.) acetic acid, reflux, 80 min; Yield given. Multistep reaction;
参考文献
Synthesis, , # 1 p. 52 - 53
反应条件
Oxonereg;; sodium hydrogencarbonate in water; acetone
参考文献
Ashford; Grega
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1523 - 1524
