4-溴-3-甲基苯甲酸甲酯合成路线 （共 30 条）
反应条件
N-bromosuccinmide in chloroform T=70°C; 48 h; Inert atmosphere;
参考文献
MERCK SERONO S.A.; BOMBRUN, Agnes; QUATTROPANI, Anna; GONZALEZ, Jerome; DORBAIS, Jerome; KNIGHT, Chris; BAKER-GLENN, Charles
Patent: WO2012/4287 A1, 2012 ;
Location in patent: Page/Page column 66 ;
WO 2012/004287 A1
反应条件
1.1: lithium borohydride / tetrahydrofuran / 40.25 h / 0 - 20 °C 1.2: 0 °C 2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 22 h / 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad
Patent: WO2012/67664 A1, 2012 ;
反应条件
1: 82 percent / lithium tetrahydroborate / tetrahydrofuran / 48 h / 25 °C 2: 96 percent / dimethyl sulfoxide; oxalyl chloride; triethylamine / CH2Cl2 / 2 h / -78 - 20 °C View Scheme
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; Akama, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131016 A1, 2013 ;
反应条件
1: With water; sodium hydroxide in tetrahydrofuran T=20°C; 16 h; 2: With hydrogenchloride in water
参考文献
Sung, Moo Je; Coppola, Gary Mark; Yoon, Taeyoung; Gilmore, Thomas A.
Patent: US2011/46133 A1, 2011 ;
Location in patent: Page/Page column 53-54 ;
反应条件
1: acetic acid tert-butyl ester; potassium tert-butylate; 4-bromo-3-methyl-benzoic acid methyl ester in tetrahydrofuran 0.166667 h; 2: acetic acid tert-butyl ester With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in tetrahydrofuran
参考文献
ABBOTT LABORATORIES
Patent: WO2008/131000 A2, 2008 ;
Location in patent: Page/Page column 141 ;
WO 2008/131000 A2
反应条件
silver fluoride; Pd(CH2SiMe3)2(cod); cyclohexyl BrettPhos in toluene T=130°C; 18 h; Sealed tube;
参考文献
Massachusetts Institute of Technology
Patent: US2011/15401 A1, 2011 ;
Location in patent: Page/Page column 17 ;
反应条件
sodium carbonate; palladium diacetate in isobutyramide T=120°C; 15 h;
参考文献
PFIZER LIMITED; GIBSON, Karl Richard; GREEN, Martin Peter; UNDERWOOD, Toby James; WAKENHUT, Florian
Patent: WO2010/32200 A1, 2010 ;
Location in patent: Page/Page column 133 ;
WO 2010/032200 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; 4 h;
参考文献
Pfizer Inc
Patent: US2007/270438 A1, 2007 ;
Location in patent: Page/Page column 42 ;
US 20070270438 A1
反应条件
in N-methyl-acetamide
参考文献
Karl Thomae GmbH
Patent: US5607944 A1, 1997 ;
反应条件
in N,N-dimethyl-formamide Heating;
参考文献
Corbett; Dirico; Song; Boscoe; Doran; Boyer; Qiu; Ammirati; VanVolkenburg; McPherson; Parker; Cox
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6707 - 6713
