1-(噻吩-3-基)乙醇合成路线 （共 17 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Press, Jeffery B.; McNally, James J.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1571 - 1581
反应条件
in tetrahydrofuran T=0°C; 2 h;
参考文献
SAN-EI GEN F.F.I., INC.
Patent: EP1854791 A1, 2007 ;
Location in patent: Page/Page column 26 ;
反应条件
sodium hydroxide in diethyl ether
参考文献
Ortho Pharmaceutical Corporation
Patent: US4775757 A1, 1988 ;
反应条件
1: thien-3-yl bromide With n-butyllithium in tetrahydrofuran; hexane T=-10°C; 1 h; 2: acetaldehyde in tetrahydrofuran; hexane 0.166667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/41813 A1, 2004 ;
Location in patent: Page 106-107 ;
WO 2004/041813 A1
反应条件
in tetrahydrofuran; diethyl ether T=0°C; Grignard addition;
参考文献
Hatano, Manabu; Ito, Orie; Suzuki, Shinji; Ishihara, Kazuaki
Chemical Communications, 2010 , vol. 46, # 15 p. 2674 - 2676
反应条件
1: ethylmagnesium bromide With zinc(II) chloride in tetrahydrofuran T=20°C; 0.75 h; Inert atmosphere; 2: 1-thiophen-3-yl-ethanone in tetrahydrofuran T=0°C; 3 h; Inert atmosphere;
参考文献
Hatano, Manabu; Ito, Orie; Suzuki, Shinji; Ishihara, Kazuaki
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5008 - 5016
反应条件
1: 2-monochloropropane in tetrahydrofuran T=20°C; 1 h; 2: 1-thiophen-3-yl-ethanone in tetrahydrofuran T=0°C; 2 h;
参考文献
Hatano, Manabu; Suzuki, Shinji; Ishihara, Kazuaki
Journal of the American Chemical Society, 2006 , vol. 128, # 31 p. 9998 - 9999
反应条件
1: diethylzinc With C56H43N2OP in toluene T=-35°C; 0.5 h; Inert atmosphere; 2: 1-thiophen-3-yl-ethanone in toluene T=-65°C; 96 h; Inert atmosphere; enantioselective reaction;
参考文献
Calvillo-Barahona, Mercedes; Cordovilla, Carlos; Genov, Miroslav N.; Martinez-Ilarduya, Jesus M.; Espinet, Pablo
Dalton Transactions, 2013 , vol. 42, # 40 p. 14576 - 14582
反应条件
diethyl ether T=-70°C;
参考文献
Gronowitz
Arkiv foer Kemi, 1958 , vol. 12, p. 533,543
反应条件
n-butyllithium 1.) ether; Yield given. Multistep reaction;
参考文献
Abarca, Belen; Ballesteros, Rafael; Enriquez, Emilio; Jones, Gurnos
Tetrahedron, 1987 , vol. 43, # 1 p. 269 - 274
