反应条件
1.1: sulfuric acid; 4-nitro-phenol / 48 h / 135 °C 1.2: 0 °C / pH 3 - 5 2.1: thionyl chloride / 12 h / 0 - 65 °C 3.1: water; ammonia / methanol / 12 h / 45 °C 4.1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C 4.2: pH 7 5.1: hydrogen / Raney-Ni / ammonia; methanol / 16 h / 20 °C / 760.05 Torr View Scheme
参考文献
RHIZEN PHARMACEUTICALS SA; INCOZEN THERAPEUTICS PVT. LTD.; VAKKALANKA, Swaroop Kumar Venkata Satya; NAGARATHNAM, Dhanapalan; VISWANADHA, Srikant; MUTHUPPALANIAPPAN, Meyyappan; BABU, Govindarajulu; BHAVAR, Prashant K
Patent: WO2013/144737 A2, 2013 ;